Killer Tomatoes Strike Back! is a 1991 American comedy film. It is the third in the Killer Tomatoes film series, following Attack of the Killer Tomatoes (1978) and Return of the Killer Tomatoes (1988), and followed by Killer Tomatoes Eat (1992). The film stars Rick Rockwell, Crystal Carson, Steve Lundquist, John Witherspoon and John Astin.

The film is the first in which the killer tomatoes are shown with faces, and the only Killer Tomatoes film that does not begin with the traditional Killer Tomatoes score, although remixes play during the film. The film was a direct-to-video release.